Medicinal Organic Synthesis Research Group
SMART DECISION // UEF // PHARMACY
News from our research group.
Just published results revealed details on species differences on Couamrin metabolis. Researchers from several collaborating research groups showed that substituted 7-hydroxycoumarins undergo sulfonation metabolism in different rates in different animal species. Also, the substitution of coumarins affected the rate of metabolism. Results give important knowledge on metabolism in mammalians that can be used to understand...
Finnish National Agency for Education has funded the Medicinal Organic Synthesis Research Group with a Edufi Fellowship. The grant was awarded to Dr Timonen and stipendiate to whom the grant was pointed is Pharm.D. Seydhamed Maljaei. Congratulations Hamed and welcome to continue your work on January 2020! The Edufi Fellowship is grant for a foreign...
The Kuopio University Foundation has awarded Dr. Timonen a personal working grant for his research on LAT1-targeted boron carriers for BNCT treatment of malignant brain tumors. The research aims to development of novel amino acid based compounds that can be used in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. BNCT is a novel...
Dr Juri Timonen published an Invited short Perspective article on L-type Amino Acid Transporter type-1 (LAT1) targeted Boron neutron Capture Therapy (BNCT) in General Chemistry. Article sets the current state of research on boronated amino acids, developments of LAT1-research and advances in BNCT falities. The topic is currently interesting as the world’s first hospital based...
A new and efficient method to synthetize di-iodinated alkenes was published in ACS Omega. The study was done in collaboration with Dr. Petri Turhanen, who has invented and studied extensively the use of Dowex(R) as a catalyst in organic reactions . In the published method, a recyclable ion-exchange resin was used to catalyze iodination of...
The Finnish Chemical society awarded Dr Juri Timonen a Honorary Medal of the Finnish Chemical Society. The president of Finnish Chemical Society, Pekka Joensuu handed the Medal for Dr Timonen “for his remarkable and indispensable work for the Society” in the Society’s 100 anniversary celebration conference. Also our collaborator, Professor Vesa-Pekka Lehto from the Pharmaceutical...
Recently, an article by Professor Risto Juvonen in collaboration with Medicinal Organic Synthesis Research Group was published in Planta medica. Most intereting results were differences in metabolism of coumarins between species. The full text article can be read at: https://www.researchgate.net/publication/330976257_Metabolism_of_Scoparone_in_Experimental_Animals_and_Humans
A research published in Heterocyclic chemistry shed new light on the anti-inflammatory effects of substituted psoralen derivatives. Dr Timonen showed in collaboration with the Immunopharmacology Research group from the School of Medicine, University of Tampere that psoralens, a certain group of furocoumarins, exhibits anti-inflammatory properties against NO production and iNOS expression. In the study, it...