Medicinal Organic Synthesis Research Group
SMART DECISION // UEF // PHARMACY
Anna Olkkonen, a BSc from the School of biomedicine (University of Eastern Finland) started recently her MSc thesis in our research group. Her thesis focuses in the computational study of TRPA1 attenuators. During the summer, she will build model of TRPA1 ion channel, study the different binding sites and predict the different binding modes for...
Our recent reviev article “Recent Advances on Molecular Modeling Studies of Transient Receptor Potential Ankyrin 1” published in Medicine Research wasselected for the journal’s 2021 #1 issue covre story. The review article writen by MSc. Carita Sallomy, Adj Prof Maija Lahtela-Kakkonen and Dr. Juri Timonen is the first literature review of different computtional studies of...
The Björkqvist foundation has awarded FM Carita Sallomy a study grant for her Docotral thesis. The Björkqvist Foundation is a local foundation that fumds resaearchers from Kangasala. The grant was awarded for Sallomy’s studoes that are aiming to identify the binding site of stilbenoid-like TRPA1 antagonists and utilize this knowledge into the design of novel...
The Finnish Cultural Foundation has granted 32 500 € for the design, synthesis and evaluation of boron containing amino acids for treatment of malignant brain tumors. The study aims to development of novel amino acid-based boron carriers to be used in boron neutron capture therapy (BNCT) of malignant brain tumors. The BNCT is a method...
Our newest MSc studnet, Satu Rotso-Liuttu has recently started her Master thesis study in Pharmacy. BSc Rotso-Liuttu is carrying out studies on computational drug design aiming to TRPA1 attenuators. The studies carried out in her MSc thesis are aiming to shed light into the binding of stilbenoids and stilbenoids like molecules into the TRPA1 protein....
A collaborative study entitled “Addressing the Biochemical Foundations of a Glucose-Based “Trojan Horse”-Strategy to Boron Neutron Capture Therapy: From Chemical Synthesis to In Vitro Assessment” with the Filip Ekholm’s research group was recently published in Molecular Pharmaceutics. The study revealed novel carboranyl-glucose conjugates to be potential molecules to be used as boron carriers in BNCT of malignant...
Just published extensive literature review written by several researchers from University of Eastern Finland and over ten other universities combines together results of over 300 research articles. The main author, Dines M. Pardhi worked in MOS research group on research of antimicrobial strategies during 2017-19. The article was published in International Journal of Pharmaceutics on...
A new master student will start soon working in our synthesis lab! A research chemistry from Jonesuu, Landry Amamea will carry out his master’s thesis work on synthesis of novel boronated amino acids. Amamea has received his Bachelor’s degree from the Department of Chemistry, University of Eastern Finland. Professor Juha Roucinen from the Department of...
Just published article reports synthesis and evaluation of novel LAT1-tareted amino acid conjugates of a known anti-cancer agent, chlorambucil. Two conjugates were synthetized by coupling chlorambucil with the aromatic ring of phenylalanine via amide and ester bond. Compounds were evaluated for their affinity to LAT1 and their uptake in vitro using a human breast canver...
Päivikki and Sakari Sohlberg foundation has awarded Dr. Timonen 17 000 € reserch funding for studies on novel boron carriers for LAT1-targeted boron neutron capture therapy (BNCT). The grant will be used to hire a PhD student to cary out synthesis and evaluation of novel boronated amino acid dervatives.