Medicinal Organic Synthesis Research Group
SMART DECISION // UEF // PHARMACY
The Finnish Cultural Foundation has granted 32 500 € for the design, synthesis and evaluation of boron containing amino acids for treatment of malignant brain tumors. The study aims to development of novel amino acid-based boron carriers to be used in boron neutron capture therapy (BNCT) of malignant brain tumors. The BNCT is a method...
A collaborative study entitled “Addressing the Biochemical Foundations of a Glucose-Based “Trojan Horse”-Strategy to Boron Neutron Capture Therapy: From Chemical Synthesis to In Vitro Assessment” with the Filip Ekholm’s research group was recently published in Molecular Pharmaceutics. The study revealed novel carboranyl-glucose conjugates to be potential molecules to be used as boron carriers in BNCT of malignant...
A new master student will start soon working in our synthesis lab! A research chemistry from Jonesuu, Landry Amamea will carry out his master’s thesis work on synthesis of novel boronated amino acids. Amamea has received his Bachelor’s degree from the Department of Chemistry, University of Eastern Finland. Professor Juha Roucinen from the Department of...
Päivikki and Sakari Sohlberg foundation has awarded Dr. Timonen 17 000 € reserch funding for studies on novel boron carriers for LAT1-targeted boron neutron capture therapy (BNCT). The grant will be used to hire a PhD student to cary out synthesis and evaluation of novel boronated amino acid dervatives.
The Kuopio University Foundation has awarded Dr. Timonen a personal working grant for his research on LAT1-targeted boron carriers for BNCT treatment of malignant brain tumors. The research aims to development of novel amino acid based compounds that can be used in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. BNCT is a novel...
Dr Juri Timonen published an Invited short Perspective article on L-type Amino Acid Transporter type-1 (LAT1) targeted Boron neutron Capture Therapy (BNCT) in General Chemistry. Article sets the current state of research on boronated amino acids, developments of LAT1-research and advances in BNCT falities. The topic is currently interesting as the world’s first hospital based...