Medicinal Organic Synthesis Research Group
SMART DECISION // UEF // PHARMACY
Just published article reports synthesis and evaluation of novel LAT1-tareted amino acid conjugates of a known anti-cancer agent, chlorambucil. Two conjugates were synthetized by coupling chlorambucil with the aromatic ring of phenylalanine via amide and ester bond. Compounds were evaluated for their affinity to LAT1 and their uptake in vitro using a human breast canver...
Just published results revealed details on species differences on Couamrin metabolis. Researchers from several collaborating research groups showed that substituted 7-hydroxycoumarins undergo sulfonation metabolism in different rates in different animal species. Also, the substitution of coumarins affected the rate of metabolism. Results give important knowledge on metabolism in mammalians that can be used to understand...
A new and efficient method to synthetize di-iodinated alkenes was published in ACS Omega. The study was done in collaboration with Dr. Petri Turhanen, who has invented and studied extensively the use of Dowex(R) as a catalyst in organic reactions . In the published method, a recyclable ion-exchange resin was used to catalyze iodination of...
Recently, an article by Professor Risto Juvonen in collaboration with Medicinal Organic Synthesis Research Group was published in Planta medica. Most intereting results were differences in metabolism of coumarins between species. The full text article can be read at: https://www.researchgate.net/publication/330976257_Metabolism_of_Scoparone_in_Experimental_Animals_and_Humans
A research published in Heterocyclic chemistry shed new light on the anti-inflammatory effects of substituted psoralen derivatives. Dr Timonen showed in collaboration with the Immunopharmacology Research group from the School of Medicine, University of Tampere that psoralens, a certain group of furocoumarins, exhibits anti-inflammatory properties against NO production and iNOS expression. In the study, it...