Medicinal Organic Synthesis Research Group
SMART DECISION // UEF // PHARMACY
A new master student will start soon working in our synthesis lab! A research chemistry from Jonesuu, Landry Amamea will carry out his master’s thesis work on synthesis of novel boronated amino acids. Amamea has received his Bachelor’s degree from the Department of Chemistry, University of Eastern Finland. Professor Juha Roucinen from the Department of...
Just published article reports synthesis and evaluation of novel LAT1-tareted amino acid conjugates of a known anti-cancer agent, chlorambucil. Two conjugates were synthetized by coupling chlorambucil with the aromatic ring of phenylalanine via amide and ester bond. Compounds were evaluated for their affinity to LAT1 and their uptake in vitro using a human breast canver...
The Kuopio University Foundation has awarded Dr. Timonen a personal working grant for his research on LAT1-targeted boron carriers for BNCT treatment of malignant brain tumors. The research aims to development of novel amino acid based compounds that can be used in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. BNCT is a novel...
Dr Juri Timonen published an Invited short Perspective article on L-type Amino Acid Transporter type-1 (LAT1) targeted Boron neutron Capture Therapy (BNCT) in General Chemistry. Article sets the current state of research on boronated amino acids, developments of LAT1-research and advances in BNCT falities. The topic is currently interesting as the world’s first hospital based...