A new master student will start soon working in our synthesis lab! A research chemistry from Jonesuu, Landry Amamea will carry out his master’s thesis work on synthesis of novel boronated amino acids. Amamea has received his Bachelor’s degree from the Department of Chemistry, University of Eastern Finland. Professor Juha Roucinen from the Department of...
Tag: Synthesis
Novel LAT1-targeted Chlorambucil Conjugates
Just published article reports synthesis and evaluation of novel LAT1-tareted amino acid conjugates of a known anti-cancer agent, chlorambucil. Two conjugates were synthetized by coupling chlorambucil with the aromatic ring of phenylalanine via amide and ester bond. Compounds were evaluated for their affinity to LAT1 and their uptake in vitro using a human breast canver...
Funding for Cancer Research
Päivikki and Sakari Sohlberg foundation has awarded Dr. Timonen 17 000 € reserch funding for studies on novel boron carriers for LAT1-targeted boron neutron capture therapy (BNCT). The grant will be used to hire a PhD student to cary out synthesis and evaluation of novel boronated amino acid dervatives.
Funding For Cancer Research
The Kuopio University Foundation has awarded Dr. Timonen a personal working grant for his research on LAT1-targeted boron carriers for BNCT treatment of malignant brain tumors. The research aims to development of novel amino acid based compounds that can be used in Boron Neutron Capture Therapy (BNCT) of malignant brain tumors. BNCT is a novel...
A Green Method For Preparing Di-iodo Alkenes
A new and efficient method to synthetize di-iodinated alkenes was published in ACS Omega. The study was done in collaboration with Dr. Petri Turhanen, who has invented and studied extensively the use of Dowex(R) as a catalyst in organic reactions . In the published method, a recyclable ion-exchange resin was used to catalyze iodination of...
New Light Shed to Anti-Inflammatory Effect of Psoralens
A research published in Heterocyclic chemistry shed new light on the anti-inflammatory effects of substituted psoralen derivatives. Dr Timonen showed in collaboration with the Immunopharmacology Research group from the School of Medicine, University of Tampere that psoralens, a certain group of furocoumarins, exhibits anti-inflammatory properties against NO production and iNOS expression. In the study, it...