Miscellaneous Projects

Our research group continues to carry out several collaborative and trial projects for miscellaneous topics. Below are listed some of these recent projects; most relating to green chemistry (in collaboration with Dr. Petri Turhanen), prodrugs, or amino acid chemistry (in collaboration with Prof. Jarkko Rautio).

Development of greener methodologies

This project came into fruition from a short research visit in 2018 to Dr Petri Turhanen’s laboratory in order to explore a novel Turhanen-Vepsäläinen method: a versatile one-pot synthetic method that utilizes oven-dried Dowex(R) ion-exchange resin and sodium iodide. We have found that, in specific conditions, the Dowex H+/NaI approach can be used to prepare differently iodinated alkenes. Dr. Turhanen has published a number of interesting publications related to a vast number of different reactions carried out using dried ion-exchange resin. The first article concerning this project’s iodination studies was published in 2019.[1]

Prodrugs of Known Anti Cancer Agents

Several projects, aimed to investigate improvements of known anti-cancer agents, have been carried out in close collaboration with Professor Jarkko Rautio’s group in recent years. The prodrug research group, led by Professor Rautio, has solid and diverse experiences concerning development of novel prodrugs and utilization of different approaches to improve transportation, cell uptake, and physico-chemical properties of a wide variety of molecules. Some of these projects are aimed to study the synthesis of LAT1 -targeting compounds, while others are aimed to the development of better delivery from gut to blood or to improve the solubility of poorly soluble drugs. We researched in collaboration with the University of Khon Kaen (Thailand) with a few of these projects, also. The most recent paper from this collaboration was published in 2020.[2]

[1] Timonen, J. M., & Turhanen, P. A. (2019). ACS omega, 4(11), 14663-14668.
[2]Pocasap, P., et al., (2020). International Journal of Molecular Sciences, 21(6), 2132-2147.