A Cover story published!

Our recent reviev article “Recent Advances on Molecular Modeling Studies of Transient Receptor Potential Ankyrin 1” published in Medicine Research wasselected for the journal’s 2021 #1 issue covre story. The review article writen by MSc. Carita Sallomy, Adj Prof Maija Lahtela-Kakkonen and Dr. Juri Timonen is the first literature review of different computtional studies of...

A collaborative study on boron carriers

A collaborative study entitled “Addressing the Biochemical Foundations of a Glucose-Based “Trojan Horse”-Strategy to Boron Neutron Capture Therapy: From Chemical Synthesis to In Vitro Assessment” with the Filip Ekholm’s research group was recently published in Molecular Pharmaceutics. The study revealed novel carboranyl-glucose conjugates to be potential molecules to be used as boron carriers in BNCT of malignant...

Review on Anti-bacterial Nanomaterials

Just published extensive literature review written by several researchers from University of Eastern Finland and over ten other universities combines together results of over 300 research articles. The main author, Dines M. Pardhi worked in MOS research group on research of antimicrobial strategies during 2017-19. The article was published in International Journal of Pharmaceutics on...

Novel LAT1-targeted Chlorambucil Conjugates

Just published article reports synthesis and evaluation of novel LAT1-tareted amino acid conjugates of a known anti-cancer agent, chlorambucil. Two conjugates were synthetized by coupling chlorambucil with the aromatic ring of phenylalanine via amide and ester bond. Compounds were evaluated for their affinity to LAT1 and their uptake in vitro using a human breast canver...

New Details of Coumarin Metabolism

Just published results revealed details on species differences on Couamrin metabolis. Researchers from several collaborating research groups showed that substituted 7-hydroxycoumarins undergo sulfonation metabolism in different rates in different animal species. Also, the substitution of coumarins affected the rate of metabolism. Results give important knowledge on metabolism in mammalians that can be used to understand...

Future Perspectives of LAT1 Targeted BNCT

Dr Juri Timonen published an Invited short Perspective article on L-type Amino Acid Transporter type-1 (LAT1) targeted Boron neutron Capture Therapy (BNCT) in General Chemistry. Article sets the current state of research on boronated amino acids, developments of LAT1-research and advances in BNCT falities. The topic is currently interesting as the world’s first hospital based...

New Research on Coumarin Metabolism Just Published!

Recently, an article by Professor Risto Juvonen in collaboration with Medicinal Organic Synthesis Research Group was published in Planta medica. Most intereting results were differences in metabolism of coumarins between species. The full text article can be read at: https://www.researchgate.net/publication/330976257_Metabolism_of_Scoparone_in_Experimental_Animals_and_Humans

New Light Shed to Anti-Inflammatory Effect of Psoralens

A research published in Heterocyclic chemistry shed new light on the anti-inflammatory effects of substituted psoralen derivatives. Dr Timonen showed in collaboration with the Immunopharmacology Research group from the School of Medicine, University of Tampere that psoralens, a certain group of furocoumarins, exhibits anti-inflammatory properties against NO production and iNOS expression. In the study, it...

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